Skip to product information
1 of 1

Primojel®

Primojel®

Sodium Starch Glycolate

Primojel® Sodium starch glycolate is a superdisintegrant suitable for a variety of tablet and capsule formulations. In higher concentrations, Primojel® can act as a dissolution enhancing agent. Primojel® is highly effective when used intragranular and/or extragranular in granular formulations.

Size
Regular price $1,106.00
Regular price Sale price $1,106.00
Unit price $22.12  per  kg
Sale Restocking
Tax included.

Product description

Disintegration performance

Primojel® takes up more than 20 times its own weight of water. Rapid water penetration into the tablets and powerful swelling results in rapid disintegration. The swelling actions makes Primojel® most effective in non-soluble matrices. Studies show that Primojel® takes up more water than comparative products on the market and develops a strong disintegrating force making it a highly effective product. The botanic source, degree of cross-linking and degree of substitution of Primojel® have been optimized in order to give rapid water uptake by the polymer without the formation of a viscous gel that may impede water penetration into the tablet.



In direct compression

The recommended starting point is 2%w/w to 4%w/w of Primojel®. The figure shows how the disintegration time of various placebo tablets (250 mg / 9 mm tablets containing 4%w/w Primojel® and 0.5%w/w magnesium stearate) is maintained after storage for 6 months at 40˚C / 75% RH in open containers. The disintegration of reference tablets stored for 6 months under ambient laboratory conditions is also shown. This data confirms that Primojel® remains an effective superdisintegrant.



In wet granulation

We recommend that Primojel® is incorporated at least partly (50% or more) during the granulation. This is especially important when a high proportion of insoluble diluent is employed. The intragranular components were wet granulated (high shear), dried, sieved and blended with the extragranular portion of Primojel® and magnesium stearate. Tablets were compressed at 250 mg and dissolution tested in 900ml of water using USP apparatus 2. Dissolution of Diclofenac Sodium is slower when Primojel® is used only in the extragranular phase. If lactose is used instead of dibasic calcium phosphate, then the effect of Primojel® location is greatly reduced.



Typical product data

Source
Potato starch

pH
6.7

Disintegration mechanism
Swelling and wicking

Product specifications

Hausner ratio 1,46
Production site: Foxhol, the Netherlands 

Packaging

- 50Kg drum with PE liner

- Sample size: 500g

Shelf life: 5 years

Product delivery

Expected delivery within 5-7 days. Each order ships with Certificate of Analysis, Material Safety Data Sheet and Product Data Sheet.

Frequently asked questions

View full details