Primojel®
Superdisintegrant

Specifications
Density | Tapped density | g/l |
Bulk density | g/l | |
Particle size | D10 | μm |
D50 | μm | |
D90 | μm | |
Hausner ratio | 1,46 | |
Production site |
Foxhol, the Netherlands | |
Conforms to USP-NF, Ph.Eur., JP |
Expected delivery within 5-7 days. Each order ships with Certificate of Analysis, Material Safety Data Sheet and Product Data Sheet.
Fast delivery
Halal and kosher certificates
Best Pharmaceutical grade lactose
Small quantities
Additional information
Disintegration performance
Primojel® takes up more than 20 times its own weight of water. Rapid water penetration into the tablets and powerful swelling results in rapid disintegration. The swelling actions makes Primojel® most effective in non-soluble matrices. Studies show that Primojel® takes up more water than comparative products on the market and develops a strong disintegrating force making it a highly effective product. The botanic source, degree of cross-linking and degree of substitution of Primojel® have been optimized in order to give rapid water uptake by the polymer without the formation of a viscous gel that may impede water penetration into the tablet.
In direct compression
The recommended starting point is 2%w/w to 4%w/w of Primojel®. The figure shows how the disintegration time of various placebo tablets (250 mg / 9 mm tablets containing 4%w/w Primojel® and 0.5%w/w magnesium stearate) is maintained after storage for 6 months at 40˚C / 75% RH in open containers. The disintegration of reference tablets stored for 6 months under ambient laboratory conditions is also shown. This data confirms that Primojel® remains an effective superdisintegrant.
In wet granulation
We recommend that Primojel® is incorporated at least partly (50% or more) during the granulation. This is especially important when a high proportion of insoluble diluent is employed. The intragranular components were wet granulated (high shear), dried, sieved and blended with the extragranular portion of Primojel® and magnesium stearate. Tablets were compressed at 250 mg and dissolution tested in 900ml of water using USP apparatus 2. Dissolution of Diclofenac Sodium is slower when Primojel® is used only in the extragranular phase. If lactose is used instead of dibasic calcium phosphate, then the effect of Primojel® location is greatly reduced.
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